02150naa a2200265 a 450000100080000000500110000800800410001902400260006010000200008624500990010626000090020552013720021465000230158665000280160965000260163765000260166370000220168970000250171170000210173670000210175770000190177870000240179770000240182177300390184510063632015-09-01       2015    bl uuuu     u00u1 u    #d7 a10.3390/v70418532DOI1 aABREU, P. M. V.  aA Current Overview of the Papaya meleira virus, an Unusual Plant Virus.h[electronic resource]  c2015  aPapaya meleira virus (PMeV) is the causal agent of papaya sticky disease, which is characterized by a spontaneous exudation of fluid and aqueous latex from the papaya fruit and leaves. The latex oxidizes after atmospheric exposure, resulting in a sticky feature on the fruit from which the name of the disease originates. PMeV is an isometric virus particle with a double-stranded RNA (dsRNA) genome of approximately 12 Kb. Unusual for a plant virus, PMeV particles are localized on and linked to the polymers present in the latex. The ability of the PMeV to inhabit such a hostile environment demonstrates an intriguing interaction of the virus with the papaya. A hypersensitivity response is triggered against PMeV infection, and there is a reduction in the proteolytic activity of papaya latex during sticky disease. In papaya leaf tissues, stress responsive proteins, mostly calreticulin and proteasome-related proteins, are up regulated and proteins related to metabolism are down-regulated. Additionally, PMeV modifies the transcription of several miRNAs involved in the modulation of genes related to the ubiquitin-proteasome system. Until now, no PMeV resistant papaya genotype has been identified and roguing is the only viral control strategy available. However, a single inoculation of papaya plants with PMeV dsRNA delayed the progress of viral infection.  aDsRNA genome virus  aLaticifers colonization  aPapaya sticky disease  aPhytopathogenic virus1 aANTUNES, T. F. S.1 aMAGAÑA-ÁLVAREZ, A.1 aPÉREZ-BRITO, D.1 aTAPIA-TUSSEL, R.1 aVENTURA, J. A.1 aFERNANDES, A. A. R.1 aFERNANDES, P. M. B.  tVirusesgv. 7, p. 1853-1870, 2015.