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| Registros recuperados : 559 | |
| 521. |  | COSTA, A. F. da.; OLIVEIRA, A. R. de.; TEIXEIRA, C. P.; TARDIN, F. D.; COSTA, H.; VENTURA, J. A.; BALBINO, J. M. de S.; PREZOTTI, L. C.; FORNAZIER, M. J.; LEAL, N. R.; PEREIRA, V. A. Recomendação de cultivares de morangueiro : 'aromas' e 'diamante'. Vitória, ES: Incaper, 2009. (Incaper. Documentos, 174).| Biblioteca(s): Biblioteca Rui Tendinha. |
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| 522. | | COSTA, A. de F. S. da.; COSTA, A. N. da.; VENTURA, J. A.; FANTON, C. J.; LIMA, I. de M.; CAETANO, L. C. S.; SANTANA, E. N. de. (Ed.). Recomendações técnicas para o cultivo do maracujazeiro. Vitória, ES : Incaper, 2008. 55 p. (Incaper. Documentos, 162).| Biblioteca(s): Biblioteca Rui Tendinha; Santa Teresa. |
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| 523. | | MARTINS, D. dos S.; FANTON, C. J.; MALAVASI, A.; URAMOTO, K.; VENTURA, J. A.; COSTA, H.; FORNAZIER, M. J.; SANTOS, F. A. M. dos; BARRETO, F. C.; AMARAL JUNIOR, R. P. do. Redução de risco de infestação de moscas-das-frutas e afídeos na cultura do mamoeiro no Estado do Espírito Santo. In: SIMPÓSIO INTERNO DE PESQUISA, DESENVOLVIMENTO E INOVAÇÃO, 1., 2004, Vitória. Resumo das ações de pesquisa, desenvolvimento e inovações tecnológicas. Vitória, ES : Incaper, p. 122-123, 2005. (Incaper. Documentos, 140).| Biblioteca(s): Biblioteca Rui Tendinha. |
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| 524. | | MELLO, B. L. B de.; CAETANO, L. C. S.; PACHECO, B. M.; LEONEL, F. de P.; FERNANDES, A. M.; VENTURA, J. A.; ESPOSTI, M. D.; FIGUEIREDO, M. R. P.; GONÇALVES, S. S. M.; VINHA, M. B. Silagem dos subprodutos do abacaxizeiro : alternativa para alimentação de bovinos. Vitória, ES: Incaper, 2020. (Incaper. Documentos, 273).| Biblioteca(s): Biblioteca Rui Tendinha. |
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| 525. | | FERRÃO, R. G.; FERRÃO, R. G.; FONSECA, A. F. A. da.; VERDIN FILHO, A. C.; VOLPI, P. S.; DE MUNER, L. H.; VENTURA, J. A.; DAHER, F, de A.; GOMES, W. R.; FERRÃO, L. M. V. Variedade clonal Vitória de café conilon para o Estado do Espírito Santo. In: SIMPÓSIO INTERNO DE PESQUISA, DESENVOLVIMENTO E INOVAÇÃO, 1., 2004, Vitória. Resumo das ações de pesquisa, desenvolvimento e inovações tecnológicas. Vitória, ES : Incaper, p. 76-77, 2005. (Incaper. Documentos, 140).| Biblioteca(s): Biblioteca Rui Tendinha. |
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| 526. | | SOUZA, C. A. S.; FANTON, C. J.; SANTANA, E. N. de.; COSTA, H.; LIMA, I. de M.; VENTURA, J. A.; LANI, J. A.; AGUILAR, M. A. G.; MARTINS, M. V. V.; SIQUEIRA, P. R. A vassoura-de-bruxa no estado do Espírito Santo. 1 ed. Vitória, ES : Incaper, 2007. (Incaper. Documentos, 153).| Biblioteca(s): Biblioteca Rui Tendinha; São Gabriel da Palha. |
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| 527. | | SALLES, T. S.; MENESES, M. D. F.; CALDAS, L. A.; SÁ-GUIMARÃES, T. E.; OLIVEIRA, D. M. de; VENTURA, J. A.; AZEVEDO, R. C.; KUSTER, R. M.; SOARES, M. R.; FERREIRA, D. F. Virucidal and antiviral activities of pomegranate (Punica granatum) extract against the mosquito-borne Mayaro virus. Parasites Vectors, v. 14, n. 44, 2021.| Biblioteca(s): Biblioteca Rui Tendinha. |
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| 528. | | VENTURA, J. A.; SILVA, S. de O. e.; GOMES, J. A.; ARLEU, R. J.; COSTA, H.; GASPARATTO, L.; PEREIRA, J. C. R.; PEREIRA, M. C. N.; PACOVA, B. E. V. Vitória e Japira : novas cultivares de bananeira. Vitória, ES : Incaper, 2005. (Incaper. Documentos, 142).| Biblioteca(s): Biblioteca Rui Tendinha. |
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| 529. | | VENTURA, J. A.; SILVA, S. de O.; GOMES, J. A.; ARLEU, R. J. A.; COSTA, H.; GASPARATTO,L.; PEREIRA, J. C. R.; PEREIRA, M. C. N.; PACOVA, B. E. V. Vitória e Japira : novas cultivares de bananeira. 4 ed. Vitória, ES : Incaper, 2011. (Incaper. Documentos, 142).| Biblioteca(s): Biblioteca Rui Tendinha. |
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| 530. | | PIMENTEL, E. F.; MENEZES PRIMO, R. B. de.; PEREIRA, A. C. H.; VIEIRA, T. Z.; LENZ. D.; ANDRADE, T. U.; RUAS, F. G.; VENTURA, J. A.; MAIA, J. F.; ENDRINGER, D. C. Sapucaia (Lecythis pisonis Camb.) a rich nutritional source and characterization of arils a new consumption approach. In: BRAZILIAN CONFERENCE ON NATURAL PRODUCTS, 6.; ANNUAL MEETING ON MICROMOLECULAR EVOLUTION, SYSTEMATICS AND ECOLOGY, 32., 2017, Vitória. Anais... Vitória: UFES, 2017. Pôster.| Biblioteca(s): Biblioteca Rui Tendinha. |
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| 531. | | MELO, M. P. de; MATOS, K. S.; MOREIRA, S. I.; SILVA, F. F.; CONCEIÇÃO, G. H.; NECHET, K.; HALFELD-VIEIRA, B. A.; BESERRA JUNIOR, J. E. A.; VENTURA, J. A.; COSTA, H.; FURTADO, E. L.; ALVES, E.; CERESINI, P. C. Two new Ceratobasidium species causing white thread blight on tropical plants in Brazil. Trop. plant pathoL, 2018.| Biblioteca(s): Biblioteca Rui Tendinha. |
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| 532. | | ZANÚNCIO JUNIOR, J. S.; FORNAZIER, M. J.; ANDREAZZA, F.; CULIK, M. P.; MENDONÇA, L. de P.; OLIVEIRA, E. E.; MARTINS, D. dos S.; FORNAZIER, M. L.; COSTA, H.; VENTURA, J. A. Spread of Two Invasive Flies (Diptera: Drosophilidae) Infesting Commercial Fruits in Southeastern Brazil. Florida Entomologist, V. 101, N. 3, p. 522-525, 2018.| Biblioteca(s): Biblioteca Rui Tendinha. |
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| 533. | | MARTINS, D. dos S.; FORNAZIER, M. J.; ZANÚNCIO JUNIOR, J. S.; VENTURA, J. A.; CULIK, M. P.; FORNAZIER, M. L.; KROHLING, C. A.; FORNAZIER, D. L.; BOTACIM, L. A.; DORZENONI, R. R. Status de coffea canephora como hospedeiro de tefritídeos e lonqueídeos no Estado do Espírito Santo, Brasil. In: SIMPÓSIO DE PESQUISA DOS CAFÉS DO BRASIL, 10., 2019, Vitória. Pesquisa, inovação e sustentabilidade dos cafés do Brasil: anais... Vitória: Consórcio Pesquisa Café, 2019.| Biblioteca(s): Biblioteca Rui Tendinha. |
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| 534. | | MAXIMINO, S. C.; DUTRA, J. A. P.; RODRIGUES, R. P.; GONÇALVES, R. de C. R.; MORAIS, P. A. B.; VENTURA, J. A.; SCHUENCK, R. P.; LACERDA JÚNIOR, V.; KITAGAWA, R. R.; BORGES, W. de S. Synthesis of eugenol derivatives and evaluation of their antifungal activity against Fusarium solani f. sp. piperis. Current Pharmaceutical Design, v. 26, p. 1-11, 2020.| Biblioteca(s): Biblioteca Rui Tendinha. |
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| 535. | | FERRÃO, R. G.; FONSECA, A. F. A. da.; FERRÃO, M. A. G.; VERDIN FILHO, A. C.; VOLPI, P. S.; MUNER, L. H. de.; LANI, J. A.; PREZOTTI, L. C.; VENTURA, J. A.; MARTINS, D. dos S.; MAURI, A. L.; MARQUES, E. M. G.; ZUCATELI, F. Café conilon: técnicas de produção com variedades melhoradas. 4 ed. Vitória, ES: Incaper, 2012. 73 (Incaper. Circular Técnica, 03-I).| Biblioteca(s): Biblioteca Rui Tendinha; Santa Teresa; São Gabriel da Palha; Sooretama. |
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| 536. | | FERRÃO, R. G.; FONSECA, A. F. A. da.; FERRÃO, M. A. G.; VERDIN FILHO, A. C.; VOLPI, P. S.; MUNER, L. H. de.; LANI, J. A.; PREZOTTI, L. C.; VENTURA, J. A.; MARTINS, D. dos S.; MAURI, A. L.; MARQUES, E. M. G.; ZUCATELI, F. Café conilon : técnicas de producción con variedades mejoradas. 4 ed. Vitória, ES: Incaper, 2012. 76 (Incaper. Circular Técnica, 03-I).| Biblioteca(s): Biblioteca Rui Tendinha; São Gabriel da Palha. |
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| 537. | | MAURASTONI, M.; ANTUNES, T. F. S.; ABREU, E. F. M.; RIBEIRO, S. G.; MEHTA, A.; SANCHES, M. M.; FONTES, W.; KITAJIMA, E. W.; CRUZ, F. T.; SANTOS, A. M. C.; VENTURA, J. A.; GOMES, A. C. M. M.; ZERBINI, F. M.; SOSA-ACOSTA, P.; NOGUEIRA, F. C. S.; RODRIGUES, S. P.; ARAGÃO, F. J. L.; WHITFIELD, A. E.; FERNANDES, P. M. B. A capsid protein fragment of a Toti-like Virus Found in Carica papaya Latex interacts with the 50S ribosomal protein L17 Viruses, v. 15, n. 541, p. 1-20, 2023.| Biblioteca(s): Biblioteca Rui Tendinha. |
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| 538. | | MARTINS, D. dos S.; VENTURA, J. A.; PAULA, R. de C. A. L.; FORNAZIER, M. J.; REZENDE, J. A. M.; CULIK, M. P.; FERREIRA, P. S. F.; PERONTI, A. L. B. G.; CARVALHO, R. C. Z. de.; SOUSA-SILVA, C. R. Aphid vectors of Papaya ringspot virus and their weed hosts in orchards in the major papaya producing and exporting region of Brazil. CROP PROTECTION, v. 90, p. 191?196, 2016.| Biblioteca(s): Biblioteca Rui Tendinha. |
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| 539. | | SOUZA, J. L. de.; PREZOTTI, L. C.; COSTA, H.; VENTURA, J. A.; FORNAZIER, M. J.; PEREIRA, V. A.; CARMO, C. A. S. do.; BOREL, R. M. A.; GARCIA, R. D. C.; BALBINO, J. M. de S.; GUARÇONI M., A.; ABAURRE, M. E. O.; ROCHA, M. A. M.; MARSARO JÚNIOR, A. L. Conhecimentos tecnológicos para o cultivo orgânico de hortaliças, milho e feijão no Espírito Santo. Vitória, ES: Incaper, 2011. 128 p. (Incaper. Documentos, 194)| Biblioteca(s): Biblioteca Rui Tendinha; Santa Teresa; São Gabriel da Palha; Sooretama. |
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| 540. | | FERRÃO, R. G.; FONSECA, A. F. A. da.; FERRÃO, M. A. G.; VERDIN FILHO, A. C.; VOLPI, P. S.; MUNER, L. H. de.; LANI, J. A.; PREZOTTI, L. C.; VENTURA, J. A.; MARTINS, D. dos S.; MAURI, A. L.; MARQUES, E. M. G.; ZUCATELI, F. Conilon coffee : production techniques with improved varieties. 4 ed. Vitória, ES: Incaper, 2012 75 (Incaper. Circular Técnica, 03-I)| Biblioteca(s): Biblioteca Rui Tendinha; São Gabriel da Palha. |
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| Registros recuperados : 559 | |
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Registro Completo |
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Biblioteca(s): |
Biblioteca Rui Tendinha. |
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Data corrente: |
05/07/2020 |
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Data da última atualização: |
05/07/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
MAXIMINO, S. C.; DUTRA, J. A. P.; RODRIGUES, R. P.; GONÇALVES, R. de C. R.; MORAIS, P. A. B.; VENTURA, J. A.; SCHUENCK, R. P.; LACERDA JÚNIOR, V.; KITAGAWA, R. R.; BORGES, W. de S. |
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Afiliação: |
Sarah C. Maximino; Jessyca Aparecida Paes Dutra; Ricardo Pereira Rodrigues; Rita de Cássia Ribeiro Gonçalves; Pedro Alves Bezerra de Morais; Jose Aires Ventura, Incaper; Ricardo Pinto Schuenck; Valdemar Lacerda Júnior; Rodrigo Rezende Kitagawa; Warley de Souza Borges. |
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Título: |
Synthesis of eugenol derivatives and evaluation of their antifungal activity against Fusarium solani f. sp. piperis. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Current Pharmaceutical Design, v. 26, p. 1-11, 2020. |
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Idioma: |
Inglês |
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Conteúdo: |
Background: Fusarium solani f. sp. piperis is a phytopathogen that causes one of the most destructive diseases in black pepper crops, resulting in significant economic and crop production losses. Consequently, the control of this fungal disease is a matter of current and relevant interest in agriculture. Objective: The objective was to synthesize eugenol derivatives with antifungal activity. Methods: In this study, using bimolecular nucleophilic substitution and click chemistry approaches, four new and three known eugenol derivatives were obtained. The eugenol derivatives were characterized and their antifungal and cytotoxic effects were evaluated. Results: Eugenol derivative 4 (2-(4-allyl-2-methoxyphenoxy)-3-chloronaphthalene-1,4-dione) was the most active against F. solani f. sp. piperis and showed acceptable cytotoxicity. Compound 4 was two-fold more effective than tebuconazole in an antifungal assay and presented similar cytotoxicity in macrophages. The in silico study of β-glucosidase suggests a potential interaction of 4 with amino acid residues by a cation-π interaction with residue Arg177 followed by a hydrogen bond with Glu596, indicating an important role in the interactions with 4, justifying the antifungal action of this compound. In addition, the cytotoxicity after metabolism was evaluated as a mimic assay with the S9 fraction in HepG2 cells. Compound 4 demonstrated maintenance of cytotoxicity, showing IC50 values of 11.18 ± 0.5 and 9.04 ± 0.2 μg mL-1 without and with the S9 fraction, respectively. In contrast, eugenol (257.9 ± 0.4 and 133.5 ± 0.8 μg mL-1), tebuconazole (34.94 ± 0.2 and 26.76 ± 0.17 μg mL-1) and especially carbendazim (251.0 ± 0.30 and 34.7 ± 0.10 μg mL-1) showed greater cytotoxicity after hepatic biotransformation. Conclusion: The results suggest that 4 is a potential candidate for use in the design of new and effective compounds that could control this pathogen. MenosBackground: Fusarium solani f. sp. piperis is a phytopathogen that causes one of the most destructive diseases in black pepper crops, resulting in significant economic and crop production losses. Consequently, the control of this fungal disease is a matter of current and relevant interest in agriculture. Objective: The objective was to synthesize eugenol derivatives with antifungal activity. Methods: In this study, using bimolecular nucleophilic substitution and click chemistry approaches, four new and three known eugenol derivatives were obtained. The eugenol derivatives were characterized and their antifungal and cytotoxic effects were evaluated. Results: Eugenol derivative 4 (2-(4-allyl-2-methoxyphenoxy)-3-chloronaphthalene-1,4-dione) was the most active against F. solani f. sp. piperis and showed acceptable cytotoxicity. Compound 4 was two-fold more effective than tebuconazole in an antifungal assay and presented similar cytotoxicity in macrophages. The in silico study of β-glucosidase suggests a potential interaction of 4 with amino acid residues by a cation-π interaction with residue Arg177 followed by a hydrogen bond with Glu596, indicating an important role in the interactions with 4, justifying the antifungal action of this compound. In addition, the cytotoxicity after metabolism was evaluated as a mimic assay with the S9 fraction in HepG2 cells. Compound 4 demonstrated maintenance of cytotoxicity, showing IC50 values of 11.18 ± 0.5 and 9.04 ± 0.2 μg... Mostrar Tudo |
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Thesagro: |
Doença de planta; Fungo; Fusarium; Fusarium solani; Pimenta; Pimenta do reino; Pimenta do reino preta. |
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Thesaurus NAL: |
Antifungal; Cytotoxicity; Eugenol derivatives; Piper nigrum. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 03014naa a2200361 a 4500
001 1022236
005 2020-07-05
008 2020 bl uuuu u00u1 u #d
100 1 $aMAXIMINO, S. C.
245 $aSynthesis of eugenol derivatives and evaluation of their antifungal activity against Fusarium solani f. sp. piperis.$h[electronic resource]
260 $c2020
520 $aBackground: Fusarium solani f. sp. piperis is a phytopathogen that causes one of the most destructive diseases in black pepper crops, resulting in significant economic and crop production losses. Consequently, the control of this fungal disease is a matter of current and relevant interest in agriculture. Objective: The objective was to synthesize eugenol derivatives with antifungal activity. Methods: In this study, using bimolecular nucleophilic substitution and click chemistry approaches, four new and three known eugenol derivatives were obtained. The eugenol derivatives were characterized and their antifungal and cytotoxic effects were evaluated. Results: Eugenol derivative 4 (2-(4-allyl-2-methoxyphenoxy)-3-chloronaphthalene-1,4-dione) was the most active against F. solani f. sp. piperis and showed acceptable cytotoxicity. Compound 4 was two-fold more effective than tebuconazole in an antifungal assay and presented similar cytotoxicity in macrophages. The in silico study of β-glucosidase suggests a potential interaction of 4 with amino acid residues by a cation-π interaction with residue Arg177 followed by a hydrogen bond with Glu596, indicating an important role in the interactions with 4, justifying the antifungal action of this compound. In addition, the cytotoxicity after metabolism was evaluated as a mimic assay with the S9 fraction in HepG2 cells. Compound 4 demonstrated maintenance of cytotoxicity, showing IC50 values of 11.18 ± 0.5 and 9.04 ± 0.2 μg mL-1 without and with the S9 fraction, respectively. In contrast, eugenol (257.9 ± 0.4 and 133.5 ± 0.8 μg mL-1), tebuconazole (34.94 ± 0.2 and 26.76 ± 0.17 μg mL-1) and especially carbendazim (251.0 ± 0.30 and 34.7 ± 0.10 μg mL-1) showed greater cytotoxicity after hepatic biotransformation. Conclusion: The results suggest that 4 is a potential candidate for use in the design of new and effective compounds that could control this pathogen.
650 $aAntifungal
650 $aCytotoxicity
650 $aEugenol derivatives
650 $aPiper nigrum
650 $aDoença de planta
650 $aFungo
650 $aFusarium
650 $aFusarium solani
650 $aPimenta
650 $aPimenta do reino
650 $aPimenta do reino preta
700 1 $aDUTRA, J. A. P.
700 1 $aRODRIGUES, R. P.
700 1 $aGONÇALVES, R. de C. R.
700 1 $aMORAIS, P. A. B.
700 1 $aVENTURA, J. A.
700 1 $aSCHUENCK, R. P.
700 1 $aLACERDA JÚNIOR, V.
700 1 $aKITAGAWA, R. R.
700 1 $aBORGES, W. de S.
773 $tCurrent Pharmaceutical Design$gv. 26, p. 1-11, 2020.
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