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Registro Completo |
Biblioteca(s): |
Biblioteca Rui Tendinha. |
Data corrente: |
05/07/2020 |
Data da última atualização: |
05/07/2020 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
MAXIMINO, S. C.; DUTRA, J. A. P.; RODRIGUES, R. P.; GONÇALVES, R. de C. R.; MORAIS, P. A. B.; VENTURA, J. A.; SCHUENCK, R. P.; LACERDA JÚNIOR, V.; KITAGAWA, R. R.; BORGES, W. de S. |
Afiliação: |
Sarah C. Maximino; Jessyca Aparecida Paes Dutra; Ricardo Pereira Rodrigues; Rita de Cássia Ribeiro Gonçalves; Pedro Alves Bezerra de Morais; Jose Aires Ventura, Incaper; Ricardo Pinto Schuenck; Valdemar Lacerda Júnior; Rodrigo Rezende Kitagawa; Warley de Souza Borges. |
Título: |
Synthesis of eugenol derivatives and evaluation of their antifungal activity against Fusarium solani f. sp. piperis. |
Ano de publicação: |
2020 |
Fonte/Imprenta: |
Current Pharmaceutical Design, v. 26, p. 1-11, 2020. |
Idioma: |
Inglês |
Conteúdo: |
Background: Fusarium solani f. sp. piperis is a phytopathogen that causes one of the most destructive diseases in black pepper crops, resulting in significant economic and crop production losses. Consequently, the control of this fungal disease is a matter of current and relevant interest in agriculture. Objective: The objective was to synthesize eugenol derivatives with antifungal activity. Methods: In this study, using bimolecular nucleophilic substitution and click chemistry approaches, four new and three known eugenol derivatives were obtained. The eugenol derivatives were characterized and their antifungal and cytotoxic effects were evaluated. Results: Eugenol derivative 4 (2-(4-allyl-2-methoxyphenoxy)-3-chloronaphthalene-1,4-dione) was the most active against F. solani f. sp. piperis and showed acceptable cytotoxicity. Compound 4 was two-fold more effective than tebuconazole in an antifungal assay and presented similar cytotoxicity in macrophages. The in silico study of β-glucosidase suggests a potential interaction of 4 with amino acid residues by a cation-π interaction with residue Arg177 followed by a hydrogen bond with Glu596, indicating an important role in the interactions with 4, justifying the antifungal action of this compound. In addition, the cytotoxicity after metabolism was evaluated as a mimic assay with the S9 fraction in HepG2 cells. Compound 4 demonstrated maintenance of cytotoxicity, showing IC50 values of 11.18 ± 0.5 and 9.04 ± 0.2 μg mL-1 without and with the S9 fraction, respectively. In contrast, eugenol (257.9 ± 0.4 and 133.5 ± 0.8 μg mL-1), tebuconazole (34.94 ± 0.2 and 26.76 ± 0.17 μg mL-1) and especially carbendazim (251.0 ± 0.30 and 34.7 ± 0.10 μg mL-1) showed greater cytotoxicity after hepatic biotransformation. Conclusion: The results suggest that 4 is a potential candidate for use in the design of new and effective compounds that could control this pathogen. MenosBackground: Fusarium solani f. sp. piperis is a phytopathogen that causes one of the most destructive diseases in black pepper crops, resulting in significant economic and crop production losses. Consequently, the control of this fungal disease is a matter of current and relevant interest in agriculture. Objective: The objective was to synthesize eugenol derivatives with antifungal activity. Methods: In this study, using bimolecular nucleophilic substitution and click chemistry approaches, four new and three known eugenol derivatives were obtained. The eugenol derivatives were characterized and their antifungal and cytotoxic effects were evaluated. Results: Eugenol derivative 4 (2-(4-allyl-2-methoxyphenoxy)-3-chloronaphthalene-1,4-dione) was the most active against F. solani f. sp. piperis and showed acceptable cytotoxicity. Compound 4 was two-fold more effective than tebuconazole in an antifungal assay and presented similar cytotoxicity in macrophages. The in silico study of β-glucosidase suggests a potential interaction of 4 with amino acid residues by a cation-π interaction with residue Arg177 followed by a hydrogen bond with Glu596, indicating an important role in the interactions with 4, justifying the antifungal action of this compound. In addition, the cytotoxicity after metabolism was evaluated as a mimic assay with the S9 fraction in HepG2 cells. Compound 4 demonstrated maintenance of cytotoxicity, showing IC50 values of 11.18 ± 0.5 and 9.04 ± 0.2 μg... Mostrar Tudo |
Thesagro: |
Doença de planta; Fungo; Fusarium; Fusarium solani; Pimenta; Pimenta do reino; Pimenta do reino preta. |
Thesaurus NAL: |
Antifungal; Cytotoxicity; Eugenol derivatives; Piper nigrum. |
Categoria do assunto: |
H Saúde e Patologia |
Marc: |
LEADER 03014naa a2200361 a 4500 001 1022236 005 2020-07-05 008 2020 bl uuuu u00u1 u #d 100 1 $aMAXIMINO, S. C. 245 $aSynthesis of eugenol derivatives and evaluation of their antifungal activity against Fusarium solani f. sp. piperis.$h[electronic resource] 260 $c2020 520 $aBackground: Fusarium solani f. sp. piperis is a phytopathogen that causes one of the most destructive diseases in black pepper crops, resulting in significant economic and crop production losses. Consequently, the control of this fungal disease is a matter of current and relevant interest in agriculture. Objective: The objective was to synthesize eugenol derivatives with antifungal activity. Methods: In this study, using bimolecular nucleophilic substitution and click chemistry approaches, four new and three known eugenol derivatives were obtained. The eugenol derivatives were characterized and their antifungal and cytotoxic effects were evaluated. Results: Eugenol derivative 4 (2-(4-allyl-2-methoxyphenoxy)-3-chloronaphthalene-1,4-dione) was the most active against F. solani f. sp. piperis and showed acceptable cytotoxicity. Compound 4 was two-fold more effective than tebuconazole in an antifungal assay and presented similar cytotoxicity in macrophages. The in silico study of β-glucosidase suggests a potential interaction of 4 with amino acid residues by a cation-π interaction with residue Arg177 followed by a hydrogen bond with Glu596, indicating an important role in the interactions with 4, justifying the antifungal action of this compound. In addition, the cytotoxicity after metabolism was evaluated as a mimic assay with the S9 fraction in HepG2 cells. Compound 4 demonstrated maintenance of cytotoxicity, showing IC50 values of 11.18 ± 0.5 and 9.04 ± 0.2 μg mL-1 without and with the S9 fraction, respectively. In contrast, eugenol (257.9 ± 0.4 and 133.5 ± 0.8 μg mL-1), tebuconazole (34.94 ± 0.2 and 26.76 ± 0.17 μg mL-1) and especially carbendazim (251.0 ± 0.30 and 34.7 ± 0.10 μg mL-1) showed greater cytotoxicity after hepatic biotransformation. Conclusion: The results suggest that 4 is a potential candidate for use in the design of new and effective compounds that could control this pathogen. 650 $aAntifungal 650 $aCytotoxicity 650 $aEugenol derivatives 650 $aPiper nigrum 650 $aDoença de planta 650 $aFungo 650 $aFusarium 650 $aFusarium solani 650 $aPimenta 650 $aPimenta do reino 650 $aPimenta do reino preta 700 1 $aDUTRA, J. A. P. 700 1 $aRODRIGUES, R. P. 700 1 $aGONÇALVES, R. de C. R. 700 1 $aMORAIS, P. A. B. 700 1 $aVENTURA, J. A. 700 1 $aSCHUENCK, R. P. 700 1 $aLACERDA JÚNIOR, V. 700 1 $aKITAGAWA, R. R. 700 1 $aBORGES, W. de S. 773 $tCurrent Pharmaceutical Design$gv. 26, p. 1-11, 2020.
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Biblioteca Rui Tendinha (BRT) |
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Biblioteca |
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Registro Completo |
Biblioteca(s): |
Biblioteca Rui Tendinha. |
Data corrente: |
28/04/2020 |
Data da última atualização: |
04/11/2020 |
Tipo da produção científica: |
Capítulo em Livro Técnico-Científico |
Autoria: |
PARTICHELLI, G. L.; COSTA, A. F. da.; GALEANO, E. A. V.; BÁRBARA, W. P.de F.; PIASSI, M.; EGGER, V. A.; PAULINI JÚNIOR, I. J.; COSTA, H. |
Afiliação: |
Guilherme Lindner Partichelli; Andrea Ferreira da Costa, Incaper; Edileuza Aparecida Vital Galeano, Incaper; Woelpher Pierângelo de Freitas Bárbara; Mirian Piassi, Incaper; Valdinei Alves Egger; Inarei José Paulini Júnior; Helcio Costa, Incaper. |
Título: |
Análise de custos da cultura do abacate (Persea americana Mill.) no município de Venda Nova do Imigrante, ES. |
Ano de publicação: |
2020 |
Fonte/Imprenta: |
In: COSTA, A. F. da. (Ed.). Custos na agricultura da Região Serrana do Espírito Santo. São Carlos: Pedro & João Editores, cap. 2, p.19-31, 2020. |
Idioma: |
Português |
Conteúdo: |
O abacateiro (Persea americana Mill.) é na atualidade uma das rutas subtropical/tropical economicamente mais importantes do mundo (BOST; SMITH; CRANE, 2013). Possui alto valor nutricional, contendo proteínas, vitaminas A e B e níveis medianos de vitaminas D e E (DUARTE et al., 2016). Nunes et al. (2018) explicam que, o abacate possui ácidos graxos monoinsaturados que reduz as concentrações de colesterol total, triacilglicerídeos e LDL-colesterol, que são os principais atores de risco para o desenvolvimento de doenças cardiovasculares... |
Palavras-Chave: |
Abacate; Abacateiro; Custo; Produção. |
Categoria do assunto: |
-- |
URL: |
https://biblioteca.incaper.es.gov.br/digital/bitstream/123456789/4117/1/abacate-cap2.pdf
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Marc: |
LEADER 01387naa a2200253 a 4500 001 1022206 005 2020-11-04 008 2020 bl uuuu u00u1 u #d 100 1 $aPARTICHELLI, G. L. 245 $aAnálise de custos da cultura do abacate (Persea americana Mill.) no município de Venda Nova do Imigrante, ES.$h[electronic resource] 260 $c2020 520 $aO abacateiro (Persea americana Mill.) é na atualidade uma das rutas subtropical/tropical economicamente mais importantes do mundo (BOST; SMITH; CRANE, 2013). Possui alto valor nutricional, contendo proteínas, vitaminas A e B e níveis medianos de vitaminas D e E (DUARTE et al., 2016). Nunes et al. (2018) explicam que, o abacate possui ácidos graxos monoinsaturados que reduz as concentrações de colesterol total, triacilglicerídeos e LDL-colesterol, que são os principais atores de risco para o desenvolvimento de doenças cardiovasculares... 653 $aAbacate 653 $aAbacateiro 653 $aCusto 653 $aProdução 700 1 $aCOSTA, A. F. da. 700 1 $aGALEANO, E. A. V. 700 1 $aBÁRBARA, W. P.de F. 700 1 $aPIASSI, M. 700 1 $aEGGER, V. A. 700 1 $aPAULINI JÚNIOR, I. J. 700 1 $aCOSTA, H. 773 $tIn: COSTA, A. F. da. (Ed.). Custos na agricultura da Região Serrana do Espírito Santo. São Carlos: Pedro & João Editores, cap. 2, p.19-31, 2020.
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